We already know that cannabis lowers sperm count, but new research suggests that the drug actually causes changes to the sperm itself - which might have implications for the health of a potential baby.大家都告知大麻不容易降低精子总数，但新的研究强调，大麻本质上或导致精子自身产生变化--有可能对即将出生于的小宝宝的身心健康造成危害。For a study published today in the journal Epigenetics, scientists at Duke University compared the sperm of two groups of rats: those who had been given tetrahydrocannabinol (THC), the psychoactive ingredient in cannabis, and those who had not. Then they compared the sperm of 24 human men who smoked marijuana weekly versus a control group who used marijuana no more than 10 times in their life and not at all in the past half-year. In both cases - rats and humans - marijuana changed how genes work in sperm cells.《表观遗传学》刊物今天公布发布了一篇研究：康涅狄格大学的生物学家将2组大鼠的精子进行了比照：一组大鼠被静脉输液了四氢大麻醇（THC，大麻中的精神实质特异性成份），另一组没。以后，她们核查了每星期大麻大麻的24位男士的精子与一生中用以大麻不高达10次的男士对照实验（以往大半年不曾吸完）的精子。
在这里二种状况下--大鼠和人们--大麻都变化了遗传基因在精子体细胞中的具有。Think of your DNA as a list of instructions for making proteins, and genes as small subsets of that list. Our body has little chemical tags (called methyl groups) that get added to the DNA at specific regions, explains Susan Kay Murphy, a professor of gynecology at Duke and co-author of the study. These chemicals dont mutate the genes themselves, but they do affect how theyre used, like deciding which instructions are followed and which arent.将DNA看作造成蛋白的命令目录，并将遗传基因看作目录中的非空子集。我的身体彻底没能够在特殊地区加到DNA中的有机化学标识（称之为羟基），康涅狄格大学的妇科学专家教授及其本研究的协同创作者珍妮·凯·艾利森表明道。
这种有机化学物自身会变化遗传基因，但他们不容易危害基础的用以方法，比如：什么命令该遵照，什么不可遵照。In both rats and humans, the cannabis affected many different genes involved in two different pathways. (Think of pathways as another set of instructions, this time for regulating various bodily functions.) One is important for organs to reach full size, and one plays a role in cancer and suppressing tumors. That just blows my mind, says Murphy. How do you even reconcile that, biologically, an entire pathway is going to be affected by these changes?在大鼠和人们的试验中，大麻危害了涉及二种各有不同方式的很多各有不同遗传基因。
这一寻找令其我大吃一惊，艾利森说。从分子生物学视角看来，大家又该怎样商议这一转变，全部方式将不容易遭受这种转变的危害吗？This doesnt mean that smoking cannabis will lead future children to be more vulnerable to cancer. Murphy is very clear that this is a pilot study originally intended to see if cannabis even has any effect of this kind on sperm. The sample size is small, and they didnt control for the concentration of THC the human recruits smoked. The scientists did, however, measure THC in the urine and noted that more THC in the urine correlated with more changes.这并并不是讲到，大麻大麻不容易导致将要出生于的小宝宝更为易患癌病。艾利森传递的十分准确：它是一项示范点研究，目地研究大麻否不容易对精子造成危害。并且研究的取样非常少，她们并没操控试验者大麻大麻的四氢大麻醇浓度值。
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